I managed to set up a similar situation on words with friends. Of course, I played both sides. We both took turns setting up the initial board. Then with one side, I swapped letters trying to obtain "O,X,P,B,Z,E" and with the other side I swapped off "X,P,B,Z" if they came my way. It worked! At the end, I was able to play OXYPHENBUTAZONE for a meager 1372 points.
This might possible in a real game. If you manage to play OXY, HEN, and UTA in the correct positions, you may be able to draw "O,P,Z,O,N,E" for a 650 point word. This strategy should be used in combination with diversionary tactics on the opposite end of the board.
Highest Single Move "Words With Friends" Score
I managed to set up a similar situation on words with friends. Of course, I played both sides. We both took turns setting up the initial board. Then with one side, I swapped letters trying to obtain "O,X,P,B,Z,E" and with the other side I swapped off "X,P,B,Z" if they came my way. It worked! At the end, I was able to play OXYPHENBUTAZONE for a meager 1372 points. This might possible in a real game. If you manage to play OXY, HEN, and UTA in the correct positions, you may be able to draw "O,P,Z,O,N,E" for a 650 point word. This strategy should be used in combination with diversionary tactics on the opposite end of the board.